Disciplinas que não terão aulas dia 31/07/2017
QP124, QP327, QP832, QP648 e QP322
"Pot Economy and Time Economy in the Synthesis of Biologically Active Molecules".
Dr. Yujiro Hayashi, Department of Chemistry, Graduate School of Science, Tohoku University.
Data: 14 de julho - sexta-feira - Horário: 16 h.
Docente responsável: Carlos Roque Duarte Correia
Abstract: One-pot operations are an effective method for both carrying out several transformations and forming several bonds in a single-pot, while at the same time cutting out several purifications, minimizing chemical waste generation, and saving time. Thus, a one-pot reaction can be not only efficient, but also green and environmentally friendly, and “pot-economy” should be considered in planning a synthesis.
We have accomplished “one-pot” synthesis of (-)-oseltamivir without evaporation nor solvent exchange by the modification of the previous three pot synthesis. Recently we have accomplished 60 minutes total synthesis of (-)-oseltamivir for “time-economy“. We further succeeded in the multistep one continuous-flow synthesis of (-)-oseltamivir.
In the presentation, the utility of one-pot reaction and recent synthetic progress of steroid will also be described.
1. Y. Hayashi, Chem. Sci. 2016, 7, 866.
2. Y. Hayashi, S. Ogasawara, Org. Lett. 2016, 18, 3426.
3. S. Ogasawara, Y. Hayashi, Synthesis 2017, 49, 424.
Resumo do seminário com figura anexado.
"Transforming Nanocellulose into Sustainable Products through Surface Engineering".
Profa. Emily Cranston, McMaster University, Canadá
Data: 18 de julho - terça-feira
Horário: 16 h.
Local: Miniauditório - Docente responsável: Watson Loh